Neural Respiratory Drive and Arousal in Patients with Obstructive Sleep Apnea Hypopnea.

ABSTRACT:

Study objectives

It has been hypothesized that arousals after apnea and hypopnea events in patients with obstructive sleep apnea are triggered when neural respiratory drive exceeds a certain level, but this hypothesis is based on esophageal pressure data, which are dependent on flow and lung volume. We aimed to determine whether a fixed threshold of respiratory drive is responsible for arousal at the termination of apnea and hypopnea using a flow independent technique (esophageal diaphragm electromyography, EMGdi) in patients with obstructive sleep apnea.

Setting

Sleep center of state Key Laboratory of Respiratory Disease.

Patients

Seventeen subjects (two women, mean age 53 ± 11 years) with obstructive sleep apnea/hypopnea syndrome were studied.

Methods

We reco

SUBMITTER: Xiao SC 

PROVIDER: S-EPMC4434561 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature