Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level.

ABSTRACT: The heat shock response (HSR), a transcriptional response that up-regulates molecular chaperones upon heat shock, is necessary for cell survival in a stressful environment to maintain protein homeostasis (proteostasis). However, there is accumulating evidence that the HSR does not ubiquitously occur under stress conditions, but largely depends on the cell types. Despite such imbalanced HSR among different cells and tissues, molecular mechanisms by which multicellular organisms maintain their global proteostasis have remained poorly understood. Here, we report that proteostasis can be maintained by molecular chaperones not only in a cell-autonomous manner but also in a non-cell-autonomous manner. We found that elevated expression of molecular chaperones, such as Hsp40 and Hsp70, in a group

SUBMITTER: Takeuchi T 

PROVIDER: S-EPMC4434695 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature