Histamine in the basolateral amygdala promotes inhibitory avoidance learning independently of hippocampus.

ABSTRACT: Recent discoveries demonstrated that recruitment of alternative brain circuits permits compensation of memory impairments following damage to brain regions specialized in integrating and/or storing specific memories, including both dorsal hippocampus and basolateral amygdala (BLA). Here, we first report that the integrity of the brain histaminergic system is necessary for long-term, but not for short-term memory of step-down inhibitory avoidance (IA). Second, we found that phosphorylation of cyclic adenosine monophosphate (cAMP) responsive-element-binding protein, a crucial mediator in long-term memory formation, correlated anatomically and temporally with histamine-induced memory retrieval, showing the active involvement of histamine function in CA1 and BLA in different phases of memory c

SUBMITTER: Benetti F 

PROVIDER: S-EPMC4434720 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature