Unraveling novel TF-miRNA regulatory crosstalk in metastasis of Soft Tissue Sarcoma.

ABSTRACT: Cancer metastasis is a disease of extreme clinical relevance, as it is responsible for more than 90% of cancer-associated mortality. The molecular mechanism and critical regulators involved in this complex multi-stage process of metastasis is poorly deciphered in soft tissue sarcomas (STS), a heterogeneous group of rare tumors with high metastatic potential. Therefore, we aimed at identifying miRNA and transcription factor (TF) regulatory networks and paths in STS metastasis. We integrated mRNA and miRNA expression profiles with curated regulations (TF→gene, TF→miRNA, miRNA→gene) from different databases and constructed a potentially active regulatory sub-network in STS metastasis. From functional and topological analysis, we found nine novel regulators of Notch signaling sub-network which

SUBMITTER: Samantarrai D 

PROVIDER: S-EPMC4434893 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature