Estimation of the synaptic input firing rates and characterization of the stimulation effects in an auditory neuron.

ABSTRACT: To understand information processing in neuronal circuits, it is important to infer how a sensory stimulus impacts on the synaptic input to a neuron. An increase in neuronal firing during the stimulation results from pure excitation or from a combination of excitation and inhibition. Here, we develop a method for estimating the rates of the excitatory and inhibitory synaptic inputs from a membrane voltage trace of a neuron. The method is based on a modified Ornstein-Uhlenbeck neuronal model, which aims to describe the stimulation effects on the synaptic input. The method is tested using a single-compartment neuron model with a realistic description of synaptic inputs, and it is applied to an intracellular voltage trace recorded from an auditory neuron in vivo. We find that the excitatory a

SUBMITTER: Kobayashi R 

PROVIDER: S-EPMC4435043 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature