Differences in food intake of tumour-bearing cachectic mice are associated with hypothalamic serotonin signalling.

ABSTRACT:

Background

Anorexia is a common symptom among cancer patients and contributes to malnutrition and strongly impinges on quality of life. Cancer-induced anorexia is thought to be caused by an inability of food intake-regulating systems in the hypothalamus to respond adequately to negative energy balance during tumour growth. Here, we show that this impaired response of food-intake control is likely to be mediated by altered serotonin signalling and by failure in post-transcriptional neuropeptide Y (NPY) regulation.

Methods

Two tumour cachectic mouse models with different food intake behaviours were used: a C26-colon adenocarcinoma model with increased food intake and a Lewis lung carcinoma model with decreased food intake. This contrast in food intake behaviour between tumour-

SUBMITTER: Dwarkasing JT 

PROVIDER: S-EPMC4435100 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature