Global gene expression analysis in human uterine epithelial cells defines new targets of glucocorticoid and estradiol antagonism.

ABSTRACT: In preparation for embryo implantation and pregnancy, the uterine epithelium undergoes a genomic and biological transition that mediates adhesion and invasion of the blastocyst. These events resemble an inflammatory response, and the immune system likely takes an active role in the establishment and maintenance of pregnancy. Although glucocorticoids are primary mediators of the immune system, the functional role of glucocorticoid signaling in the uterine epithelium is not well defined. To investigate the dynamic relationship between glucocorticoids and reproductive hormones, we performed whole-genome microarray analysis in a human uterine endometrial cancer cell line (ECC1 cells) treated with the synthetic glucocorticoid dexamethasone (Dex) alone or in combination with estradiol (E₂). Over

SUBMITTER: Whirledge S 

PROVIDER: S-EPMC4435104 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature