Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder.

ABSTRACT:

Importance

Psychotic disorders (including schizophrenia, schizoaffective disorder, and psychotic bipolar disorder) are devastating illnesses characterized by breakdown in the integration of information processing. Recent advances in neuroimaging allow for the estimation of brain networks on the basis of intrinsic functional connectivity, but the specific network abnormalities in psychotic disorders are poorly understood.

Objective

To compare intrinsic functional connectivity across the cerebral cortex in patients with schizophrenia spectrum disorders or psychotic bipolar disorder and healthy controls.

Design, setting, and participants

We studied 100 patients from an academic psychiatric hospital (28 patients with schizophrenia, 32 patients with schizoaffective disorde

SUBMITTER: Baker JT 

PROVIDER: S-EPMC4435541 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature