C3 glomerulonephritis associated with monoclonal gammopathy: a case series.

ABSTRACT:

Background

C3 glomerulonephritis (GN) is a proliferative GN resulting from glomerular deposition of complement factors due to dysregulation of the alternative pathway of complement. Dysregulation of the alternative pathway of complement may occur as a result of mutations or functional inhibition of complement-regulating proteins. Functional inhibition of the complement-regulating proteins may result from a monoclonal gammopathy.

Study design

Case series.

Setting & participants

32 Mayo Clinic patients with C3 GN, 10 (31%) of whom had evidence of a monoclonal immunoglobulin in serum.

Outcomes

Clinical features, hematologic and bone marrow biopsy findings, kidney biopsy findings, kidney measures, complement pathway abnormalities, treatment, and follow-up of patien

SUBMITTER: Zand L 

PROVIDER: S-EPMC4435575 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature