Randomized controlled trial of lactoferrin for prevention of sepsis in peruvian neonates less than 2500 g.

ABSTRACT:

Background

Lactoferrin (LF) is a broad-spectrum antimicrobial and immunomodulatory milk glycoprotein.

Objective

To determine the effect of bovine LF on the prevention of the first episode of late-onset sepsis in Peruvian infants.

Methods

We conducted a pilot randomized placebo-controlled double blind study in infants with a birth weight (BW) less than 2500g in 3 Neonatal Units in Lima. Patients were randomized to receive bovine LF 200mg/kg/d or placebo for 4 weeks.

Results

One hundred and ninety neonates with a BW of 1591 ± 408 g and a gestational age of 32.1 ± 2.6 weeks were enrolled. Overall, 33 clinically defined first late-onset sepsis events occurred. The cumulative sepsis incidence in the LF group was 12/95 (12.6%) versus 21/95 (22.1%) in the placebo grou

SUBMITTER: Ochoa TJ 

PROVIDER: S-EPMC4435832 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature