The Association between Mycobacterium Tuberculosis Genotype and Drug Resistance in Peru.

ABSTRACT:

Background

The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the spread of tuberculosis.

Methods

To investigate the association of Mycobacterium tuberculosis bacterial genotype with drug-resistance. Drug susceptibility testing together with genotyping using both 15-loci MIRU-typing and spoligotyping, was performed on 2,139 culture positive isolates, each from a different patient in Lima, Peru. Demographic, geospatial and socio-economic data were collected using questionnaires, global positioning equipment and the latest national census.

Results

The Latin American Mediterranean (LAM) clade (OR 2.4,

SUBMITTER: Grandjean L 

PROVIDER: S-EPMC4435908 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature