Distinct fronto-striatal couplings reveal the double-faced nature of response-outcome relations in instruction-based learning.

ABSTRACT: Higher species commonly learn novel behaviors by evaluating retrospectively whether actions have yielded desirable outcomes. By relying on explicit behavioral instructions, only humans can use an acquisition shortcut that prospectively specifies how to yield intended outcomes under the appropriate stimulus conditions. A recent and largely unexplored hypothesis suggests that striatal areas interact with lateral prefrontal cortex (LPFC) when novel behaviors are learned via explicit instruction, and that regional subspecialization exists for the integration of differential response-outcome contingencies into the current task model. Behaviorally, outcome integration during instruction-based learning has been linked to functionally distinct performance indices. This includes (1) compatibility e

SUBMITTER: Ruge H 

PROVIDER: S-EPMC4436102 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature