Efficacy of corneal collagen cross-linking for treatment of keratoconus: a meta-analysis of randomized controlled trials.

ABSTRACT:

Objective

To evaluate the efficacy of corneal collagen cross-linking (CXL) for the treatment of keratoconus.

Methods

We performed a literature search for randomized controlled trials that assessed the effect of CXL in slowing progression of keratoconus. The primary outcome measures included changes of topographic parameters, visual acuity, and refraction. Efficacy estimates were evaluated by weighted mean difference (WMD) and 95% confidence interval (CI) for absolute changes of the interested outcomes.

Results

Significant decrease in mean keratometry value, maximum keratometry value and minimum keratometry value were demonstrated in the CXL group compared with the control group (WMD = -1.65; 95% CI: -2.51 to -0.80; P < 0.00001; WMD = -2.05; 95% CI: -3.10 to -1.00; P <

SUBMITTER: Li J 

PROVIDER: S-EPMC4436191 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature