Decreased memory B cells and increased CD8 memory T cells in blood of breastfed children: the generation R study.

ABSTRACT:

Background

Breastfeeding provides a protective effect against infectious diseases in infancy. Still, immunological evidence for enhanced adaptive immunity in breastfed children remains inconclusive.

Objective

To determine whether breastfeeding affects B- and T-cell memory in the first years of life.

Methods

We performed immunophenotypic analysis on blood samples within a population-based prospective cohort study. Participants included children at 6 months (n=258), 14 months (n=166), 25 months (n=112) and 6 years of age (n=332) with both data on breastfeeding and blood lymphocytes. Total B- and T-cell numbers and their memory subsets were determined with 6-color flow cytometry. Mothers completed questionnaires on breastfeeding when their children were aged 2, 6, and 12

SUBMITTER: Jansen MA 

PROVIDER: S-EPMC4436360 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature