Cilostazol attenuates ovariectomy-induced bone loss by inhibiting osteoclastogenesis.

ABSTRACT:

Background

Cilostazol has been reported to alleviate the metabolic syndrome induced by increased intracellular adenosine 3',5'-cyclic monophosphate (cAMP) levels, which is also associated with osteoclast (OC) differentiation. We hypothesized that bone loss might be attenuated via an action on OC by cilostazol.

Methodology and principal findings

To test this idea, we investigated the effect of cilostazol on ovariectomy (OVX)-induced bone loss in mice and on OC differentiation in vitro, using μCT and tartrate-resistant acid phosphatase staining, respectively. Cilostazol prevented from OVX-induced bone loss and decreased oxidative stress in vivo. It also decreased the number and activity of OC in vitro. The effect of cilostazol on reactive oxygen species (ROS) occurred via prot

SUBMITTER: Ke K 

PROVIDER: S-EPMC4436362 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature