CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex.

ABSTRACT: Experience modifies synaptic connectivity through processes that involve dendritic spine rearrangements in neuronal circuits. Although cAMP response element binding protein (CREB) has a key function in spines changes, its role in activity-dependent rearrangements in brain regions of rodents interacting with the surrounding environment has received little attention so far. Here we studied the effects of vibrissae trimming, a widely used model of sensory deprivation-induced cortical plasticity, on processes associated with dendritic spine rearrangements in the barrel cortex of a transgenic mouse model of CREB downregulation (mCREB mice). We found that sensory deprivation through prolonged whisker trimming leads to an increased number of thin spines in the layer V of related barrel cortex (Co

SUBMITTER: Pignataro A 

PROVIDER: S-EPMC4436461 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature