Enriched transcription factor signatures in triple negative breast cancer indicates possible targeted therapies with existing drugs.

ABSTRACT:

Purpose

Triple negative (TN) breast cancers which lack expression of the estrogen (ER), progesterone (PR), and human epidermal growth factor 2 (HER2) receptors convey a poor prognosis due in part to a lack of targeted therapies.

Methods

To identify viable targets for the treatment of TN disease, we have conducted a gene set enrichment analysis (GSEA) on seven different breast cancer whole genome gene expression cohorts comparing TN vs. ER + HER2 - to identify consistently enriched genes that share a common promoter motif. The seven cohorts were profiled on three different genome expression platforms (Affymetrix, Illumina and RNAseq) consisting in total of 2088 samples with IHC metadata.

Results

GSEA identified enriched gene expression patterns in TN samples that share

SUBMITTER: Willis S 

PROVIDER: S-EPMC4436509 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature