Time dynamics of protein complexes in the AD11 transgenic mouse model for Alzheimer's disease like pathology.

ABSTRACT:

Background

Many approaches exist to integrate protein-protein interaction data with other sources of information, most notably with gene co-expression data, to obtain information on network dynamics. It is of interest to look at groups of interacting gene products that form a protein complex. We were interested in applying new tools to the characterization of pathogenesis and dynamic events of an Alzheimer's-like neurodegenerative model, the AD11 mice, expressing an anti-NGF monoclonal antibody. The goal was to quantify the impact of neurodegeneration on protein complexes, by measuring the correlation between gene expression data by different metrics.

Results

Data were extracted from the gene expression profile of AD11 brain, obtained by Agilent microarray, at 1, 3, 6, 15 mo

SUBMITTER: Arisi I 

PROVIDER: S-EPMC4436769 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature