Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: a pilot study.

ABSTRACT:

Background

Cystic fibrosis (CF) leads to advanced lung disease despite aggressive care. Persistent inflammation and oxidative stress contribute to exacerbations and disease progression. Flaxseed (FS), a dietary botanical supplement with high fiber, lignan phenolics, and omega-3 fatty acids has anti-inflammatory and antioxidant properties in murine models of acute and chronic lung injury. This pilot study was designed to determine whether CF patients could tolerate FS, evaluate circulating FS metabolites, and study biomarkers of lung damage, as a prelude to studying clinical outcomes.

Methods

10 CF patients and 5 healthy volunteers consumed 40 g of FS daily for 4 weeks with safety and tolerability being assessed. Urine was evaluated for systemic oxidative stress and plasma fo

SUBMITTER: Turowski JB 

PROVIDER: S-EPMC4436808 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature