Electroencephalographic coherence and cortical acetylcholine during ketamine-induced unconsciousness.

ABSTRACT:

Background

There is limited understanding of cortical neurochemistry and cortical connectivity during ketamine anaesthesia. We conducted a systematic study to investigate the effects of ketamine on cortical acetylcholine (ACh) and electroencephalographic coherence.

Methods

Male Sprague-Dawley rats (n=11) were implanted with electrodes to record electroencephalogram (EEG) from frontal, parietal, and occipital cortices, and with a microdialysis guide cannula for simultaneous measurement of ACh concentrations in prefrontal cortex before, during, and after ketamine anaesthesia. Coherence and power spectral density computed from the EEG, and ACh concentrations, were compared between conscious and unconscious states. Loss of righting reflex was used as a surrogate for unconsciousn

SUBMITTER: Pal D 

PROVIDER: S-EPMC4436930 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature