Importance of sigma factor mutations in increased triclosan resistance in Salmonella Typhimurium.

ABSTRACT:

Background

Salmonella enterica is the second most common foodborne pathogen. The use of biocides is crucial to prevent spread of foodborne pathogens, and it would be devastating for food safety if Salmonella would become resistant to the disinfectants used. Another concern is that exposure to disinfectants might lead to decreased susceptibility to antibiotics. The current study aimed to identify genetic changes causing high level triclosan resistance in S. enterica serovar Typhimurium and evaluate how these affected antibiotic resistance and efflux pump activity.

Results

Wild type strains S. Typhimurium 4/74 and DTU3 were adapted to increasing concentrations of the biocide triclosan by serial passage. High level triclosan resistant isolates (MIC > 1000 μg/ml) were obtained.

SUBMITTER: Gantzhorn MR 

PROVIDER: S-EPMC4437202 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature