Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats.

ABSTRACT: Conditioned taste aversion (CTA) is an adaptive behavior that benefits survival of animals including humans and also serves as a powerful model to study the neural mechanisms of learning. Memory formation is a necessary component of CTA learning and involves neural processing and regulation of gene expression in the amygdala. Many studies have been focused on the identification of intracellular signaling cascades involved in CTA, but not late responsive genes underlying the long-lasting behavioral plasticity. In this study, we explored in silico experiments to identify persistent changes in gene expression associated with CTA in rats. We used oligonucleotide microarrays to identify 248 genes in the amygdala regulated by CTA. Pathway Studio and IPA software analyses showed that the differen

SUBMITTER: Panguluri SK 

PROVIDER: S-EPMC4437262 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature