Transcriptomic landscape of lncRNAs in inflammatory bowel disease.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) is a complex multi-factorial inflammatory disease with Crohn's disease (CD) and ulcerative colitis (UC) being the two most common forms. A number of transcriptional profiling studies have provided compelling evidence that describe the role of protein-coding genes and microRNAs in modulating the immune responses in IBD.

Methods

In the present study, we performed a genome-wide transcriptome profiling of lncRNAs and protein-coding genes in 96 colon pinch biopsies (inflamed and non-inflamed) extracted from multiple colonic locations from 45 patients (CD = 13, UC = 20, controls = 12) using an expression microarray platform.

Results

In our study, we identified widespread dysregulation of lncRNAs and protein-coding genes in both in

SUBMITTER: Mirza AH 

PROVIDER: S-EPMC4437449 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature