Controlled surface topography regulates collective 3D migration by epithelial-mesenchymal composite embryonic tissues.

ABSTRACT: Cells in tissues encounter a range of physical cues as they migrate. Probing single cell and collective migratory responses to physically defined three-dimensional (3D) microenvironments and the factors that modulate those responses are critical to understanding how tissue migration is regulated during development, regeneration, and cancer. One key physical factor that regulates cell migration is topography. Most studies on surface topography and cell mechanics have been carried out with single migratory cells, yet little is known about the spreading and motility response of 3D complex multi-cellular tissues to topographical cues. Here, we examine the response to complex topographical cues of microsurgically isolated tissue explants composed of epithelial and mesenchymal cell layers from n

SUBMITTER: Song J 

PROVIDER: S-EPMC4437865 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature