SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway.

ABSTRACT:

Background

SKF83959 stimulates the phospholipase Cβ/inositol phosphate 3 pathway, resulting in the activation of Ca(2+)/calmodulin-dependent kinase IIα, which affects the synthesis of brain-derived neurotrophic factor, a neurotrophic factor critical for the pathophysiology of depression. Previous reports showed that SKF83959 elicited antidepressant activity in the forced swim test and tail suspension test as a novel triple reuptake inhibitor. However, there are no studies showing the effects of SKF83959 in a chronic stress model of depression and the role of phospholipase C/inositol phosphate 3/calmodulin-dependent kinase IIα/brain-derived neurotrophic factor pathway in SKF83959-mediated antidepressant effects.

Methods

In this study, SKF83959 was firstly investigated in the

SUBMITTER: Jiang B 

PROVIDER: S-EPMC4438541 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature