Identification of targets for rational pharmacological therapy in childhood craniopharyngioma.

ABSTRACT:

Introduction

Pediatric adamantinomatous craniopharyngioma (ACP) is a histologically benign but clinically aggressive brain tumor that arises from the sellar/suprasellar region. Despite a high survival rate with current surgical and radiation therapy (75-95 % at 10 years), ACP is associated with debilitating visual, endocrine, neurocognitive and psychological morbidity, resulting in excheptionally poor quality of life for survivors. Identification of an effective pharmacological therapy could drastically decrease morbidity and improve long term outcomes for children with ACP.

Results

Using mRNA microarray gene expression analysis of 15 ACP patient samples, we have found several pharmaceutical targets that are significantly and consistently overexpressed in our panel of ACP re

SUBMITTER: Gump JM 

PROVIDER: S-EPMC4438576 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature