Identification and genome characterization of genotype B and genotype C bovine parainfluenza type 3 viruses isolated in the United States.

ABSTRACT:

Background

Bovine parainfluenza 3 viruses (BPI3V) are respiratory pathogens of cattle that cause disease singly but are often associated with bovine respiratory disease complex (BRDC) in conjunction with other viral and bacterial agents. Bovine vaccines currently contain BPI3V to provide protection against the virus, but there is no current information regarding the BPI3V strains that are circulating in the U.S.

Results

A project was initiated to sequence archival BPI3V isolates to study viral evolution over time. This was done with a deep sequencing protocol that generated sequences of multiple RNA virus genomes simultaneously. Analysis of the BPI3V sequences revealed that, in addition to the genotype A (BPI3Va) viruses previously described in the United States, there were

SUBMITTER: Neill JD 

PROVIDER: S-EPMC4438627 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature