ERK5 activation in macrophages promotes efferocytosis and inhibits atherosclerosis.

ABSTRACT:

Background

Efferocytosis is a process by which dead and dying cells are removed by phagocytic cells. Efferocytosis by macrophages is thought to curb the progression of atherosclerosis, but the mechanistic insight of this process is lacking.

Methods and results

When macrophages were fed apoptotic cells or treated with pitavastatin in vitro, efferocytosis-related signaling and phagocytic capacity were upregulated in an ERK5 activity-dependent manner. Macrophages isolated from macrophage-specific ERK5-null mice exhibited reduced efferocytosis and levels of gene and protein expression of efferocytosis-related molecules. When these mice were crossed with low-density lipoprotein receptor(-/-) mice and fed a high-cholesterol diet, atherosclerotic plaque formation was accelerated, a

SUBMITTER: Heo KS 

PROVIDER: S-EPMC4439099 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature