Ontology highlight
ABSTRACT:
SUBMITTER: Liu CC
PROVIDER: S-EPMC4439128 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20150520 5
C-Maf plays an important role in regulating cytokine production in TH cells. Its transactivation of IL-4 is optimized by phosphorylation at Tyr21, Tyr92, and Tyr131. However, the molecular mechanism regulating its tyrosine phosphorylation remains unknown. In this study, we demonstrate that Tec kinase family member Tec, but not Rlk or Itk, is a tyrosine kinase of c-Maf and that Tec enhances c-Maf-dependent IL-4 promoter activity. This effect of Tec is counteracted by Ptpn22, which physically inte ...[more]