Ontology highlight
ABSTRACT:
SUBMITTER: Yin J
PROVIDER: S-EPMC4439169 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
PLoS biology 20150520 5
Epidermal growth factor receptor variant III (EGFRvIII) has been associated with glioma stemness, but the direct molecular mechanism linking the two is largely unknown. Here, we show that EGFRvIII induces the expression and secretion of pigment epithelium-derived factor (PEDF) via activation of signal transducer and activator of transcription 3 (STAT3), thereby promoting self-renewal and tumor progression of glioma stem cells (GSCs). Mechanistically, PEDF sustained GSC self-renewal by Notch1 cle ...[more]