Associations of common variants in the BST2 region with HIV-1 acquisition in African American and European American people who inject drugs.

ABSTRACT:

Objective

The bone marrow stromal cell antigen 2 (BST2) gene encodes a host restriction factor that acts as an innate immune sensor of HIV-1 exposure and suppresses release of HIV-1 particles. We aimed to identify associations of variants in the BST2 gene region with HIV-1 acquisition and disease progression.

Design/methods

Using HIV+ cases and HIV- controls from the Urban Health Study (n=3136 African Americans and European Americans who inject drugs), we tested 470 variants in BST2 and its flanking regions for association with HIV-1 acquisition and log-transformed viral load.

Results

We found that the single nucleotide polymorphism (SNP) rs113189798 surpassed the P value threshold corrected for multiple testing. The rs113189798-G allele (frequency=16% in African Amer

SUBMITTER: Hancock DB 

PROVIDER: S-EPMC4439198 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature