Increased risk of non-alcoholic fatty liver disease after diagnosis of celiac disease.

ABSTRACT:

Background & aims

Non-alcoholic fatty liver disease is a common cause of chronic liver disease. Celiac disease alters intestinal permeability and treatment with a gluten-free diet often causes weight gain, but so far there are few reports of non-alcoholic fatty liver disease in patients with celiac disease.

Methods

Population-based cohort study. We compared the risk of non-alcoholic fatty liver disease diagnosed from 1997 to 2009 in individuals with celiac disease (n = 26,816) to matched reference individuals (n = 130,051). Patients with any liver disease prior to celiac disease were excluded, as were individuals with a lifetime diagnosis of alcohol-related disorder to minimize misclassification of non-alcoholic fatty liver disease. Cox regression estimated hazard ratios for

SUBMITTER: Reilly NR 

PROVIDER: S-EPMC4439270 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature