Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease.

ABSTRACT:

Background

Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), but the cause of this dysfunction is unclear.

Methods

Platelet mitochondrial complex I and I/III (nicotinamide adenine dinucleotide cytochrome c reductase, NCCR) activities were measured in early PD patients and matched controls enrolled in a population-based case-control study. Ambient agricultural pesticide exposures were assessed with a geographic information system and California Pesticide Use Registry.

Results

In contrast to some previous reports, we found no differences in complex I and I/III activities in subjects with PD and controls. We did find that NCCR activity correlated with subjects' exposure to pesticides known to inhibit mitochondrial activity reg

SUBMITTER: Bronstein JM 

PROVIDER: S-EPMC4439327 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature