Genetic contributions to urgency urinary incontinence in women.

ABSTRACT:

Purpose

We identify genetic variants associated with urgency urinary incontinence in postmenopausal women.

Materials and methods

A 2-stage genome-wide association analysis was conducted to identify variants associated with urgency urinary incontinence. The WHI GARNET substudy with 4,894 genotyped post-reproductive white women was randomly split into independent discovery and replication cohorts. Genome-wide imputation was performed using IMPUTE2 with the 1000 Genomes ALL Phase I integrated variant set as a reference. Controls reported no urgency urinary incontinence at enrollment or followup. Cases reported monthly or greater urgency urinary incontinence and leaked sufficiently to wet/soak underpants/clothes. Logistic regression models were used to predict urgency urinary in

SUBMITTER: Richter HE 

PROVIDER: S-EPMC4439377 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature