Surfactant protein B gene polymorphisms is associated with risk of bronchopulmonary dysplasia in Chinese Han population.

ABSTRACT:

Objective

To investigate the relationship between Surfactant protein B (SP-B) gene polymorphisms and bronchopulmonary dysplasia (BPD) development in preterm infants of China Han ethnic population.

Methods

SP-B gene polymorphisms were studied in 134 neonates who were born at <32 weeks of gestation, with the diagnosis of BPD and in a control group of 168 preterm infants without BPD. Genotyping for SP-B was performed by polymerase chain reaction (PCR) and gene sequencing.

Results

In this study, three of the SNP genotypes, -18C/A, 1580C/T and 4564T/C were common identified in SP-B gene. The -18C/A genotype was found to be significantly associated with BPD (χ2=10.741, P<0.01), with P<0.01 for the dominant model (OR=1.712, 95% CI=1.228-2.3894) and the allelic model (OR=1.78

SUBMITTER: Zhang S 

PROVIDER: S-EPMC4440115 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature