PPARG, AGTR1, CXCL16 and LGALS2 polymorphisms are correlated with the risk for coronary heart disease.

ABSTRACT:

Purpose

Our study was designed to explore the interaction between genes of PPARG, AGTR1, CXCL16 and LGALS2 and further investigate the association between genes polymorphisms and coronary heart disease (CHD).

Methods

90 CHD patients and 80 healthy individuals were enrolled in our study. Gene chip technology was used for checking four single nucleotide polymorphisms (SNPs) (PPARG rs1152002, AGTR1 rs5186, CXCL16 rs3744700 and LGALS2 rs7291467). MDR software was used to analyze gene-gene interactions. Odds ratio (OR) with 95% confidence interval (CI) were employed to evaluate the association of genes and CHD risk.

Results

Genotypes and alleles distribution in case and control groups showed significant difference (P<0.05). And there exists interaction among genes. The mod

SUBMITTER: Tian J 

PROVIDER: S-EPMC4440139 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature