Angiogenesis dysregulation in term asphyxiated newborns treated with hypothermia.

ABSTRACT:

Background

Neonatal encephalopathy following birth asphyxia is a major predictor of long-term neurological impairment. Therapeutic hypothermia is currently the standard of care to prevent brain injury in asphyxiated newborns but is not protective in all cases. More robust and versatile treatment options are needed. Angiogenesis is a demonstrated therapeutic target in adult stroke. However, no systematic study examines the expression of angiogenesis-related markers following birth asphyxia in human newborns.

Objective

This study aimed to evaluate the expression of angiogenesis-related protein markers in asphyxiated newborns developing and not developing brain injury compared to healthy control newborns.

Design/methods

Twelve asphyxiated newborns treated with hypothermi

SUBMITTER: Shaikh H 

PROVIDER: S-EPMC4440713 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature