Biodistribution and trafficking of hydrogel nanoparticles in adult mosquitoes.

ABSTRACT:

Background

Nanotechnology offers great potential for molecular genetic investigations and potential control of medically important arthropods. Major advances have been made in mammalian systems to define nanoparticle (NP) characteristics that condition trafficking and biodistribution of NPs in the host. Such information is critical for effective delivery of therapeutics and molecules to cells and organs, but little is known about biodistribution of NPs in mosquitoes.

Methodology/principal findings

PRINT technology was used to construct a library of fluorescently labeled hydrogel NPs of defined size, shape, and surface charge. The biodistribution (organ, tissue, and cell tropisms and trafficking kinetics) of positively and negatively charged 200 nm x 200 nm, 80 nm x 320 nm, a

SUBMITTER: Paquette CC 

PROVIDER: S-EPMC4440717 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature