Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins.

ABSTRACT: Aberrant regulation of RNA stability has an important role in many disease states. Deregulated post-transcriptional modulation, such as that governed by microRNAs targeting linear sequence elements in messenger RNAs, has been implicated in the progression of many cancer types. A defining feature of RNA is its ability to fold into structures. However, the roles of structural mRNA elements in cancer progression remain unexplored. Here we performed an unbiased search for post-transcriptional modulators of mRNA stability in breast cancer by conducting whole-genome transcript stability measurements in poorly and highly metastatic isogenic human breast cancer lines. Using a computational framework that searches RNA sequence and structure space, we discovered a family of GC-rich structural cis-re

SUBMITTER: Goodarzi H 

PROVIDER: S-EPMC4440807 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature