Mucosal healing in patients with celiac disease and outcomes of pregnancy: a nationwide population-based study.

ABSTRACT:

Background & aims

Studies have associated undiagnosed celiac disease with adverse outcomes of pregnancy. We investigated the association between persistent villous atrophy and outcomes of pregnancy in women with celiac disease.

Methods

We collected data on 337 women with celiac disease who gave birth (to 460 infants) within 5 years of a follow-up biopsy, from 28 pathology departments in Sweden. We compared birth outcomes from women whose follow-up biopsy showed persistent villous atrophy (Marsh score, 3; n = 142; 31% of study population) with those of women with mucosal recovery (n = 318; 69%). We used multivariable logistic regression (adjusted for maternal age, parity, country of birth, smoking, infant sex, and calendar year of birth) to evaluate the association between pe

SUBMITTER: Lebwohl B 

PROVIDER: S-EPMC4440846 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature