Turning Squalene into Cationic Lipid Allows a Delivery of siRNA in Cultured Cells.
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ABSTRACT:
SUBMITTER: Bertrand JR
PROVIDER: S-EPMC4440994 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
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Turning Squalene into Cationic Lipid Allows a Delivery of siRNA in Cultured Cells.
Bertrand Jean-Rémi JR Lucas Claire C Pham Ngoc Minh NM Durieu Catherine C Couvreur Patrick P Malvy Claude Paul CP Desmaële Didier D
Nucleic acid therapeutics 20150420 3
Covalent binding of squalene to siRNA has already been shown to be an interesting way of delivering siRNA in vivo. Whether squalene derivatives could also be used to deliver siRNA in cells without covalent binding similar to usual transfection with cationic lipids is the question addressed in this article. Accordingly, we investigated the activity of two squalene derivatives bearing a quaternary ammonium head group and a guanidinium group, respectively. The second derivative displayed interestin ...[more]
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