Agreement and repeatability of vascular reactivity estimates based on a breath-hold task and a resting state scan.

ABSTRACT: FMRI BOLD responses to changes in neural activity are influenced by the reactivity of the vasculature. By complementing a task-related BOLD acquisition with a vascular reactivity measure obtained through breath-holding or hypercapnia, this unwanted variance can be statistically reduced in the BOLD responses of interest. Recently, it has been suggested that vascular reactivity can also be estimated using a resting state scan. This study aimed to compare three breath-hold based analysis approaches (block design, sine-cosine regressor and CO2 regressor) and a resting state approach (CO2 regressor) to measure vascular reactivity. We tested BOLD variance explained by the model and repeatability of the measures. Fifteen healthy participants underwent a breath-hold task and a resting state scan w

SUBMITTER: Lipp I 

PROVIDER: S-EPMC4441043 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature