Testing for risk and protective trends in genetic analyses of HIV acquisition.

ABSTRACT: Host genetics studies of HIV-1 acquisition are critically important for the identification of new targets for drug and vaccine development. Analyses of such studies typically focus on pairwise comparisons of three different groups: HIV-1 positive individuals, HIV-1 high-risk seronegative individuals, and population controls. Because there is a clear expectation of how gene frequencies of risk or protective alleles would be ordered in the three groups, we are able to construct a statistical framework that offers a consistent increase in power over a wide-range of the magnitude of risk/protective effects. In this paper, we develop tests that constrain the alternative hypothesis to appropriately reflect risk or protective trends jointly across the three groups and show that they lead to a sub

SUBMITTER: Mccarthy JM 

PROVIDER: S-EPMC4441099 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature