Association between the dynamics of multiple replication origins and the evolution of multireplicon genome architecture in haloarchaea.

ABSTRACT: Haloarchaeal genomes are generally composed of multiple replicons, and each replicon has a single or multiple replication origin(s). The comparative genomic analysis of replication origins from closely related species can be used to reveal the evolutionary mechanisms that account for the development of multiple origin systems. Multiple replication origins have been in silico and experimentally investigated in Haloarcula hispanica, which raise the possibility for comparisons of multiple replication origins in Haloarcula species. Thus, we performed a comparison of H. hispanica replication origins with those from five additional Haloarcula species. We demonstrated that the multiple replication origins in the chromosome were evolved independently multiple times from the oriC1-dependent ancestr

SUBMITTER: Wu Z 

PROVIDER: S-EPMC4441112 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature