Adrenocortical carcinoma: clinical outcomes and prognosis of 330 patients at a tertiary care center.

ABSTRACT:

Objective

Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis. Herein, we describe the clinical features and outcomes for a large series of ACC patients.

Design and methods

Retrospective review of ACC patients seen at The University of Texas MD Anderson Cancer Center from 1998 through 2011.

Results

A total of 330 patients with median age at diagnosis of 48.5 years; 12 (3.6%) patients were under 18 years. Hormonally functioning tumors represented 41.8% (n=138) of all cases. Surgical resection for the primary tumor was done in 275 (83.3%) patients (45 at MD Anderson (16.4%)). For those who had surgical resection, the median local-recurrence-free time was 1.04 years. Factors associated with local recurrence included positive surgical margins (P=0.00

SUBMITTER: Ayala-Ramirez M 

PROVIDER: S-EPMC4441210 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature