Assessing the transport of receptor-mediated drug-delivery devices across cellular monolayers.

ABSTRACT: Receptor-mediated endocytosis (RME) has been extensively studied as a method for augmenting the transport of therapeutic devices across monolayers. These devices range from simple ligand-therapeutic conjugates to complex ligand-nanocarrier systems. However, characterizing the uptake of these carriers typically relies on their comparisons to the native therapeutic, which provides no understanding of the ligand or cellular performance. To better understand the potential of the RME pathway, a model for monolayer transport was designed based on the endocytosis cycle of transferrin, a ligand often used in RME drug-delivery devices. This model established the correlation between apical receptor concentration and transport capability. Experimental studies confirmed this relationship, demonstratin

SUBMITTER: Brewer E 

PROVIDER: S-EPMC4441268 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature