Comparative performance of gene-based warfarin dosing algorithms in a multiethnic population.

ABSTRACT:

Summary background

Gene-based warfarin dosing algorithms have largely been developed in homogeneous populations, and their generalizability has not been established.

Objectives

We sought to assess the performance of published algorithms in a racially diverse and multiethnic sample, and determine if additional clinical variables or genetic variants associated with dose could enhance algorithm performance.

Patients and methods

In 145 compliant patients on warfarin with a goal international normalized ratio (INR) of 2-3, stable, therapeutic doses were compared with predicted doses using 12 reported algorithms that incorporated CYP2C9 and VKORC1 variants. Additional covariates tested with each model included race, concurrent medications, medications known to interact with

SUBMITTER: Lubitz SA 

PROVIDER: S-EPMC4441275 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature