Associations between Serum Sex Hormone Concentrations and Whole Blood Gene Expression Profiles in the General Population.

ABSTRACT:

Background

Despite observational evidence from epidemiological and clinical studies associating sex hormones with various cardiometabolic risk factors or diseases, pathophysiological explanations are sparse to date. To reveal putative functional insights, we analyzed associations between sex hormone levels and whole blood gene expression profiles.

Methods

We used data of 991 individuals from the population-based Study of Health in Pomerania (SHIP-TREND) with whole blood gene expression levels determined by array-based transcriptional profiling and serum concentrations of total testosterone (TT), sex hormone-binding globulin (SHBG), free testosterone (free T), dehydroepiandrosterone sulfate (DHEAS), androstenedione (AD), estradiol (E2), and estrone (E1) measured by liquid chr

SUBMITTER: Haring R 

PROVIDER: S-EPMC4441431 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature