If It's Not One Thing, It's Another: An Inverse Relationship of Malignancy and Atherosclerotic Disease.

ABSTRACT: Atherosclerosis and malignancy are pervasive pathological conditions that account for the bulk of morbidity and mortality in developed countries. Our current understanding of the patholobiology of these fundamental disorders suggests that inflammatory processes may differentially affect them; thus, atherosclerosis can be largely driven by inflammation, where as cancer often flourishes as inflammatory responses are modulated. A corollary of this hypothesis is that cancer (or its treatment may significantly attenuate atherosclerotic disease by diminishing host inflammatory response, suggesting potential therapeutic approaches. To evaluate the relationship between cancer and cardiovascular atherosclerotic disease, we assessed 1,024 autopsy reports from Brigham and Women's Hospital and perform

SUBMITTER: Li M 

PROVIDER: S-EPMC4441436 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature