Genome-wide analysis of positively selected genes in seasonal and non-seasonal breeding species.

ABSTRACT: Some mammals breed throughout the year, while others breed only at certain times of year. These differences in reproductive behavior can be explained by evolution. We identified positively-selected genes in two sets of species with different degrees of relatedness including seasonal and non-seasonal breeding species, using branch-site models. After stringent filtering by sum of pairs scoring, we revealed that more genes underwent positive selection in seasonal compared with non-seasonal breeding species. Positively-selected genes were verified by cDNA mapping of the positive sites with the corresponding cDNA sequences. The design of the evolutionary analysis can effectively lower the false-positive rate and thus identify valid positive genes. Validated, positively-selected genes, including

SUBMITTER: Meng Y 

PROVIDER: S-EPMC4441472 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature